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Thursday, December 3, 2009


Kaalai neram en jannal oram…..

It was a beautiful Sunday morning… for a long time I have been thinking that there should be some general mechanism that govern the transcription and translation of proteins.. I feel that somehow I am getting to know what I wanted. As Anthony Robbins quotes in his book..… "Concerning all acts of initiative and creation, there is one elementary truth--that the moment one definitely commits oneself, then Providence moves, too"( originally by Johann Wolfgang Von Goethe)… I am slowly getting to know that quantum theory is indeed a major factor… as in that particles can be at two places at a time (though this is more related to the psychoneuroimmunology project)… the second one … mathematics of the chromatin http://www.nature.com/news/2009/090904/full/news.2009.880.html

is again promising...as in it says that euchromatin occupies a higher fractal dimensions exposing large and rough surface to the molecules interacting with it and smaller fractal dimensions of the heterochromatin makes it to have more flatter and smoother. The bulky fractal structure of euchromatin could encourage proteins to hop around over large stretches of DNA, making it easier for them to scan for their target sequences whereas the flatter structure of the heterochromatin helps them to stick close to each other facilitating the histones that r plentiful(in contrast to euchromatin regulating proteins that r more specific) to bind to and inactivate them.Moreover the inactivating protein have to move more systematically which is favored by their smaller dimensions.So the nucleus might be able to switch the behaviour of different areas of DNA simply by altering the fractal structure of chromatin. "This would be an indication that you can tune the way you search for these targets," says Huet, "by changing the structure of these targets."


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